Aspartate-474 in the first exoplasmic loop of the thyrotropin receptor is crucial for receptor activation

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The measurement technologies of thyrotropin receptor antibodies from the past to the present

Thyroid Stimulating Hormone Receptor (TSH-R) autoantibodies are the main cause of Graveschr('39') disease and its external thyroid manifestations such as ophtalmopathy and dermatopathy. These antibodies are functionally different and are commonly called TSH receptor antibodies (TRAbs). In fact, TRAbs are a set of autoantibodies including TSHR-stimulating antibodies (TSAbs), TSHR- blocking antib...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1997

ISSN: 0014-5793

DOI: 10.1016/s0014-5793(97)00256-1